Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 9/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 9/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410260 | 0.87 | NPC1 (0.53) | NPC1RAB9AKCNH2DOT1LEHMT2 | |
| SCHEMBL3408093 | 0.86 | PSEN1 (0.44) | NPC1RAB9AKCNH2DOT1LIMPDH2 | |
| SCHEMBL3408338 | 0.84 | NPC1 (0.40) | NPC1RAB9AKCNH2DOT1LEHMT2 | |
| SCHEMBL3406068 | 0.83 | NPC1 (0.46) | NPC1RAB9AKCNH2DOT1LEHMT2 | |
| SCHEMBL3411085 | 0.82 | NPC1 (0.42) | NPC1RAB9AKCNH2DOT1LEHMT2 | |
| SCHEMBL3407955 | 0.82 | NPC1 (0.51) | NPC1RAB9AKCNH2DOT1LEHMT2 | |
| SCHEMBL3406662 | 0.82 | NPC1 (0.40) | NPC1RAB9AKCNH2DOT1LEHMT2 | |
| SCHEMBL3410440 | 0.81 | NPC1 (0.36) | NPC1RAB9AKCNH2IMPDH2PSEN1 | |
| SCHEMBL3409949 | 0.80 | IMPDH2 (0.51) | NPC1RAB9AKCNH2DOT1LIMPDH2 | |
| SCHEMBL3410702 | 0.80 | USP2 (0.45) | NPC1RAB9AKCNH2DOT1LEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |