Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 11/20 | 0.40 |
| ▸ | GHSR | Q92847 | 5/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007731 | 0.87 | HTT (0.63) | HTTCYP2C9CYP2C19FBP1ALDH1A1 | |
| SCHEMBL2007331 | 0.77 | HTT (0.86) | HTTCYP2C9CYP2C19FBP1ALDH1A1 | |
| SCHEMBL3413658 | 0.76 | FBP1 (0.40) | HTTCYP2C9FBP1ALDH1A1LMNA | |
| SCHEMBL2009726 | 0.73 | HTT (0.57) | HTTCYP2C9CYP2C19FBP1ALDH1A1 | |
| SCHEMBL2010325 | 0.71 | HTT (0.54) | HTTCYP2C9CYP2C19FBP1ALDH1A1 | |
| SCHEMBL2007978 | 0.70 | HTT (0.53) | HTTCYP2C9CYP2C19FBP1ALDH1A1 | |
| SCHEMBL12067985 | 0.70 | ALDH1A1 (0.42) | HTTCYP2C9CYP2C19ALDH1A1TDP1 | |
| SCHEMBL15625510 | 0.68 | TDP1 (0.46) | HTTCYP2C9CYP2C19ALDH1A1TSHR | |
| SCHEMBL26144895 | 0.67 | TDP1 (0.45) | HTTCYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL3410882 | 0.67 | FBP1 (0.49) | HTTCYP2C9CYP2C19FBP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081889-B1 | SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-12-22 | — | — | EP | claimed |