Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | IDH2 | P48735 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CDK11B | P21127 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413260 | 0.90 | GAK (0.39) | MAPTMAPK1LMNAAPPABCG2 | |
| SCHEMBL3413137 | 0.85 | CHRNA7 (0.40) | L3MBTL1RAB9AKCNH2NPC1 | |
| SCHEMBL3412265 | 0.85 | ABCB1 (0.39) | LMNAABCG2RAB9AKCNH2CDK1 | |
| SCHEMBL3413250 | 0.84 | SLC2A1 (0.42) | LMNAABCG2RAB9AJAK2JAK3 | |
| SCHEMBL3410450 | 0.84 | NPC1 (0.38) | MAPTRAB9APTK2KCNH2NPC1 | |
| SCHEMBL3412873 | 0.84 | KCNH2 (0.45) | MAPTMAPK1LMNAAPPTDP1 | |
| SCHEMBL3406468 | 0.84 | KCNH2 (0.42) | MAPTRAB9AKCNH2CDK1PSEN1 | |
| SCHEMBL3406068 | 0.82 | NPC1 (0.46) | MAPTLMNAABCG2RAB9AKCNH2 | |
| SCHEMBL3410885 | 0.82 | NPC1 (0.44) | MAPTMAPK1LMNAAPPGAA | |
| SCHEMBL3410260 | 0.80 | NPC1 (0.53) | MAPTMAPK1ABCG2GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |