Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412873 | 0.91 | KCNH2 (0.45) | KCNH2NPC1RAB9AMAPTDOT1L | |
| SCHEMBL3410885 | 0.90 | NPC1 (0.44) | KCNH2NPC1RAB9AMAPTATM | |
| SCHEMBL3413137 | 0.90 | CHRNA7 (0.40) | KCNH2NPC1RAB9ADOT1LIMPDH2 | |
| SCHEMBL3413260 | 0.90 | GAK (0.39) | KCNH2NPC1RAB9AMAPTDOT1L | |
| SCHEMBL3410450 | 0.89 | NPC1 (0.38) | KCNH2NPC1RAB9AMAPTDOT1L | |
| SCHEMBL3406068 | 0.87 | NPC1 (0.46) | KCNH2NPC1RAB9AMAPTDOT1L | |
| SCHEMBL3410260 | 0.84 | NPC1 (0.53) | KCNH2NPC1RAB9AMAPTDOT1L | |
| SCHEMBL3412265 | 0.84 | ABCB1 (0.39) | KCNH2NPC1RAB9ADOT1LPSEN1 | |
| SCHEMBL3411030 | 0.84 | MAPT (0.41) | KCNH2NPC1RAB9AMAPTPSEN1 | |
| SCHEMBL3410316 | 0.82 | IMPDH2 (0.44) | KCNH2NPC1RAB9AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |