Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | GALR2 | O43603 | 3/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.34 |
| ▸ | GALR1 | P47211 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406468 | 0.91 | KCNH2 (0.42) | KCNH2NPC1RAB9ADOT1LIMPDH2 | |
| SCHEMBL3410885 | 0.89 | NPC1 (0.44) | KCNH2NPC1RAB9AAPPDOT1L | |
| SCHEMBL3413260 | 0.86 | GAK (0.39) | KCNH2NPC1RAB9AAPPDOT1L | |
| SCHEMBL3413137 | 0.86 | CHRNA7 (0.40) | KCNH2NPC1RAB9ADOT1LGALR2 | |
| SCHEMBL3410450 | 0.85 | NPC1 (0.38) | KCNH2NPC1RAB9ADOT1LIMPDH2 | |
| SCHEMBL3406068 | 0.85 | NPC1 (0.46) | KCNH2NPC1RAB9ADOT1LIMPDH2 | |
| SCHEMBL3411030 | 0.84 | MAPT (0.41) | KCNH2NPC1RAB9AAPPLMNA | |
| SCHEMBL3410260 | 0.83 | NPC1 (0.53) | KCNH2NPC1RAB9ADOT1LIMPDH2 | |
| SCHEMBL3413250 | 0.82 | SLC2A1 (0.42) | NPC1RAB9ALMNAHTTSLC2A1 | |
| SCHEMBL3410316 | 0.81 | IMPDH2 (0.44) | KCNH2NPC1RAB9ADOT1LIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |