Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.40 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29825302 | 0.83 | LIPE (0.63) | LIPEALDH1A1L3MBTL1GLAENPP2 | |
| SCHEMBL22704 | 0.83 | LIPE (0.63) | LIPEALDH1A1L3MBTL1GLAENPP2 | |
| SCHEMBL27990078 | 0.79 | ENPP2 (0.67) | LIPEALDH1A1L3MBTL1ENPP2HPGD | |
| SCHEMBL6360463 | 0.77 | ALDH1A1 (0.54) | LIPEALDH1A1L3MBTL1GLAHPGD | |
| 1,2-Diethoxybenzene SCHEMBL28608089 | 0.76 | L3MBTL1 (0.61) | ALDH1A1L3MBTL1GLAHPGDHSD17B10 | |
| SCHEMBL29951150 | 0.73 | ENPP2 (0.46) | LIPEALDH1A1L3MBTL1GLAENPP2 | |
| SCHEMBL14120757 | 0.73 | ENPP2 (0.46) | LIPEALDH1A1L3MBTL1GLAENPP2 | |
| SCHEMBL2318890 | 0.71 | ENPP2 (0.39) | LIPEALDH1A1L3MBTL1ENPP2ORAI1 | |
| 1,2-Diethoxybenzene SCHEMBL29428929 | 0.71 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1GLAHPGDMAPT | |
| 1,2-Diethoxybenzene SCHEMBL578986 | 0.71 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1GLAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265583-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009115425-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-24 | — | — | WO | disclosed |