Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414027 | 0.87 | CFB (0.39) | CFBADRB2ADRB1ADRB3LMNA | |
| SCHEMBL3433522 | 0.87 | CFB (0.41) | CFBADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL3414425 | 0.86 | TAAR1 (0.44) | CFBADRB2ADRB1ADRB3SLC6A2 | |
| SCHEMBL3668515 | 0.84 | CFB (0.33) | CFBADRB2ADRB1ADRB3SLC6A2 | |
| SCHEMBL3671371 | 0.83 | KCNA5 (0.33) | CFBADRB2ADRB1ADRB3FAAH | |
| SCHEMBL3415420 | 0.80 | ADRA2A (0.41) | CFBADRB2ADRB1ADRB3MAPT | |
| SCHEMBL3671172 | 0.79 | CFB (0.36) | CFBADRB2ADRB1ADRB3SLC6A2 | |
| SCHEMBL3672607 | 0.78 | P2RX7 (0.35) | CFBADRB2ADRB1ADRB3SLC6A2 | |
| SCHEMBL3668500 | 0.77 | CFB (0.35) | CFBADRB2ADRB1ADRB3MAPT | |
| SCHEMBL3411857 | 0.76 | CFB (0.36) | CFBADRA2AADRA2BADRA2CTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265269-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | Allergan, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009120648-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2009-10-01 | — | — | WO | disclosed |