Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
| ▸ | CFB | P00751 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414027 | 0.83 | CFB (0.39) | ADRB2ADRB1ADRB3CFBFAAH | |
| SCHEMBL3415102 | 0.83 | CFB (0.34) | ADRB2ADRB1ADRB3CFBFAAH | |
| SCHEMBL3433522 | 0.83 | CFB (0.41) | ADRB2ADRB1ADRB3CFBFAAH | |
| SCHEMBL3414425 | 0.82 | TAAR1 (0.44) | ADRB2ADRB1ADRB3CFB | |
| SCHEMBL3672607 | 0.79 | P2RX7 (0.35) | KCNA5ADRB2ADRB1ADRB3CFB | |
| SCHEMBL3415420 | 0.78 | ADRA2A (0.41) | ADRB2ADRB1ADRB3CFB | |
| SCHEMBL3671172 | 0.78 | CFB (0.36) | ADRB2ADRB1ADRB3CFBPOLB | |
| SCHEMBL3411857 | 0.77 | CFB (0.36) | CFBMAP4K1 | |
| SCHEMBL3668515 | 0.76 | CFB (0.33) | ADRB2ADRB1ADRB3CFB | |
| SCHEMBL1157462 | 0.75 | KCNA5 (0.35) | KCNA5CFBMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242753-A1 | OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009091760-A1 | OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2009-07-23 | — | — | WO | disclosed |