Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | CFB | P00751 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414027 | 0.92 | CFB (0.39) | ADRA2ACFBTAAR1OPRM1OPRD1 | |
| SCHEMBL3668500 | 0.87 | CFB (0.35) | ADRA2AADRA1ACFBTAAR1OPRM1 | |
| SCHEMBL3433522 | 0.84 | CFB (0.41) | ADRA2AADRA1ACFBTAAR1OPRM1 | |
| SCHEMBL3672607 | 0.84 | P2RX7 (0.35) | ADRA2ACFBTAAR1ADRB2ADRB1 | |
| SCHEMBL3414425 | 0.81 | TAAR1 (0.44) | ADRA2AADRA1ACFBTAAR1TP53 | |
| SCHEMBL3671172 | 0.81 | CFB (0.36) | ADRA2AADRA1ACFBTAAR1ADRB2 | |
| SCHEMBL3415102 | 0.80 | CFB (0.34) | ADRA2ACFBTAAR1MAPTADRB2 | |
| SCHEMBL3668515 | 0.79 | CFB (0.33) | ADRA2AADRA1ACFBTAAR1ADRB2 | |
| SCHEMBL3671371 | 0.78 | KCNA5 (0.33) | CFBADRB2ADRB1ADRB3 | |
| SCHEMBL3414412 | 0.77 | LMNA (0.42) | TAAR1OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265269-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | Allergan, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009120648-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2009-10-01 | — | — | WO | disclosed |