Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 9/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.35 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.35 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | BHMT | Q93088 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794407 | 0.80 | CASP3 (0.35) | — | |
| Aspartic Acid SCHEMBL29024585 | 0.70 | GSK3A (0.42) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL29564328 | 0.70 | GSK3A (0.42) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL7781258 | 0.69 | GRIK1 (0.57) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL135731 | 0.69 | GRIK1 (0.57) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL7781260 | 0.69 | GRIK1 (0.57) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL8386686 | 0.67 | SLC7A5 (0.61) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL8087511 | 0.67 | GRIK1 (0.54) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL8087513 | 0.67 | GRIK1 (0.54) | GRIK1GRIA4GRIK3GRIK5GRIK2 | |
| Aspartic Acid SCHEMBL3460058 | 0.67 | GRIK1 (0.44) | GRIK1GRIA4GRIK3GRIK5GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265283-A1 | AURISTATIN DRUG LINKER CONJUGATES | Seattle Genetics, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009117531-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |