Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.57 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | MMP2 | P08253 | 2/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
| ▸ | CA6 | P23280 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18296817 | 0.82 | TSHR (0.61) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL170426 | 0.82 | CA1 (0.59) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL12968291 | 0.82 | MMP2 (0.59) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL8038636 | 0.81 | CA1 (0.57) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL7363066 | 0.81 | ALDH1A1 (0.60) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL29135554 | 0.79 | LMNA (0.58) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL21561788 | 0.79 | NPSR1 (0.58) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL5177115 | 0.79 | NPSR1 (0.50) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL195196 | 0.78 | LMNA (0.56) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL19011399 | 0.78 | MMP2 (0.53) | CA1CA2MMP2MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152715-B1 | IMPROVED PROCESS FOR THE PREPARATION OF 6-ALPHA-HYDROXY-N-ALKYLATED OPIATES | MALLINCKRODT INC (US) | 2010-12-29 | — | — | EP | claimed |