Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297942 | 0.85 | MEP1B (0.50) | NOS1NOS2CHRNB2CHRNA4BCHE | |
| SCHEMBL9870414 | 0.83 | NOS1 (0.51) | NOS1NOS2CHRNB2CHRNA4BCHE | |
| SCHEMBL3719288 | 0.82 | NOS1 (0.50) | NOS1NOS2CHRNB2CHRNA4BCHE | |
| SCHEMBL6468903 | 0.81 | ALDH1A1 (0.58) | TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9871961 | 0.81 | NOS1 (0.49) | NOS1NOS2CHRNB2CHRNA4BCHE | |
| SCHEMBL10968800 | 0.80 | NOS1 (0.45) | NOS1NOS2CHRNB2CHRNA4BCHE | |
| SCHEMBL10376085 | 0.79 | ALDH1A1 (0.48) | NOS1NOS2CHRNB2CHRNA4BCHE | |
| SCHEMBL10970748 | 0.78 | FFAR1 (0.50) | BCHETSHRALDH1A1ACHEKDM4E | |
| SCHEMBL11116515 | 0.78 | NOS1 (0.44) | NOS1NOS2CHRNB2CHRNA4BCHE | |
| SCHEMBL11010000 | 0.78 | CYP2D6 (0.46) | NOS1NOS2BCHEHRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4571398-A | Cytosine derivatives having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-02-18 | — | — | US | claimed |
| EP-0140466-A2 | Pyrimidinone derivatives, process for their preparation, and their pharmaceutical use | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-05-08 | — | — | EP | claimed |
| EP-2265590-A2 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009129335-A2 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-10-22 | — | — | WO | disclosed |
| EP-0180298-B1 | PYRIMIDINE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-09-25 | — | — | EP | disclosed |
| EP-0134096-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-01 | — | — | EP | disclosed |
| US-4738969-A | Substituted aminopyridones and aminoquinolones having histamine H2 -receptor blocking activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-04-19 | — | — | US | disclosed |
| US-4694008-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-09-15 | — | — | US | disclosed |
| US-4608380-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-08-26 | — | — | US | disclosed |
| EP-0180298-A2 | Pyrimidine compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-05-07 | — | — | EP | disclosed |
| EP-0172968-A1 | Aminothiadiazine derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-03-05 | — | — | EP | disclosed |
| US-4571398-A | Cytosine derivatives having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-02-18 | — | — | US | disclosed |
| EP-0143630-A2 | Chemical compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-05 | — | — | EP | disclosed |
| EP-0140466-A2 | Pyrimidinone derivatives, process for their preparation, and their pharmaceutical use | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-05-08 | — | — | EP | disclosed |
| EP-0134096-A2 | Aminopyrimidinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-03-13 | — | — | EP | disclosed |
| EP-0041359-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLYLALKYL GUANIDINES; INTERMEDIATES AND THEIR PREPARATION | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-11-14 | — | — | EP | disclosed |
| US-4443375-A | Tetrahydroimidazo(3,4-c)-1,3-diazocine intermediates for production of guanidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-17 | — | — | US | disclosed |
| US-4375435-A | 3-,4-Dihydroimidazo (3,4-c)-1,3-pyrimidines and 4,5-dihydroimidazo (3,4-c)-1,3-diazepines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-03-01 | — | — | US | disclosed |
| EP-0041359-A1 | Process for the preparation of heterocyclylalkyl guanidines; intermediates and their preparation | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-09 | — | — | EP | disclosed |