Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | EPOR | P19235 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871961 | 0.95 | NOS1 (0.49) | NOS1NOS2HRH3CHRNB2CHRNA4 | |
| SCHEMBL9870414 | 0.92 | NOS1 (0.51) | NOS1NOS2HRH3CHRNB2CHRNA4 | |
| SCHEMBL10997614 | 0.86 | TSHR (0.53) | EPORBCHEACHE | |
| SCHEMBL10683775 | 0.84 | BCHE (0.58) | BCHE | |
| SCHEMBL10950517 | 0.84 | ACHE (0.54) | NOS1NOS2HRH3CHRNB2CHRNA4 | |
| SCHEMBL4297942 | 0.83 | MEP1B (0.50) | NOS1NOS2HRH3CHRNB2CHRNA4 | |
| SCHEMBL10955368 | 0.83 | NOS1 (0.55) | NOS1NOS2HRH3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL11110754 | 0.83 | BCHE (0.57) | BCHE | |
| SCHEMBL10664175 | 0.83 | ACHE (0.51) | BCHEACHE | |
| SCHEMBL3416236 | 0.82 | NOS1 (0.51) | NOS1NOS2HRH3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114881-A1 | ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS | PROGENRA INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-5021429-A | Histamine h2-antagonists; antisecretory-antiallergen agent; skin disorders and peptic ulcers | ALLEN & HANSBURYS LIMITED (GB) | 1991-06-04 | — | — | US | disclosed |
| US-4952589-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0181163-B1 | HETEROCYCLIC PHENOXY DERIVATIVES HAVING AN ANTIHISTAMINE H2 ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |
| US-4788184-A | Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents | BRISTOL-MYERS COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| US-4772704-A | ANTIULCER AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| US-4764612-A | SELECTIVE HISTAMINE H2-ANTAGONIST | GLAXO GROUP LIMITED (GB) | 1988-08-16 | — | — | US | disclosed |
| US-4742055-A | ANTISECRETORY, ANTIULCER | RORER PHARMACEUTICAL CORPORATION (US) | 1988-05-03 | — | — | US | disclosed |
| US-4738969-A | Substituted aminopyridones and aminoquinolones having histamine H2 -receptor blocking activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-04-19 | — | — | US | disclosed |
| US-4727081-A | ANTIULCER AGENTS | LUDWIG HEUMANN & CO. GMBH (DE) | 1988-02-23 | — | — | US | disclosed |
| US-4317819-A | Amine derivatives | GLAXO GROUP LIMITED (GB) | 1982-03-02 | — | — | US | disclosed |
| US-4304780-A | Aminoalkylthiophene derivatives as histamine H2 -antagonists | GLAXO GROUP LIMITED (GB) | 1981-12-08 | — | — | US | disclosed |
| EP-0040696-A2 | Aminothiadiazoles as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1981-12-02 | — | — | EP | disclosed |
| US-4279911-A | ANTIHISTAMINES | GLAXO GROUP LIMITED (GB) | 1981-07-21 | — | — | US | disclosed |
| US-4264614-A | HISTAMINE ANTAGONIST; ANTIALLERGENS; ANTISECRETORY AND ANTIINFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 1981-04-28 | — | — | US | disclosed |
| US-4233302-A | ANTIHISTAMINES, ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1980-11-11 | — | — | US | disclosed |
| EP-0016565-A1 | 1,2,4-Triazole derivatives, processes for their production and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1980-10-01 | — | — | EP | disclosed |
| EP-0013071-A1 | Pyrimidinone derivatives, processes for preparing them and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-07-09 | — | — | EP | disclosed |
| WO-1980000966-A1 | NEW HISTAMINE H2-ANTAGONISTS | SMITH KLINE FRENCH LAB (GB) | 1980-05-15 | — | — | WO | disclosed |
| EP-0002930-A1 | Amine derivatives, their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1979-07-11 | — | — | EP | disclosed |