Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415459 | 0.91 | MCHR1 (0.50) | DHFRDCPSNUDT1LRRK2MCHR1 | |
| SCHEMBL22834474 | 0.89 | NUDT1 (0.53) | NUDT1LRRK2GRM4 | |
| SCHEMBL18072381 | 0.78 | HDAC6 (0.44) | DHFRDCPSNUDT1LRRK2GRM4 | |
| SCHEMBL31403748 | 0.76 | DHFR (0.40) | DHFRDCPSMCHR1 | |
| SCHEMBL4883383 | 0.74 | MEN1 (0.50) | DHFRDCPSLRRK2CYP2D6 | |
| SCHEMBL3402935 | 0.74 | DHFR (0.44) | DHFRDCPSMCHR1CYP2D6GRM4 | |
| SCHEMBL4935143 | 0.74 | LOXL2 (0.52) | DHFRDCPSIRAK4GRM4 | |
| SCHEMBL30939176 | 0.74 | LOXL2 (0.52) | DHFRDCPSIRAK4GRM4 | |
| SCHEMBL24265468 | 0.73 | CYP2D6 (0.53) | DHFRDCPSLRRK2MCHR1CYP2D6 | |
| SCHEMBL15716837 | 0.73 | CCNA2 (0.43) | DHFRDCPSLRRK2IRAK4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068863-A2 | PYRIMIDINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-06-17 | — | — | WO | claimed |