Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41106 | 0.90 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| Dimethylamine SCHEMBL1333133 | 0.89 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL27476414 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL1483105 | 0.84 | AKR1B1 (0.50) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL18343637 | 0.83 | AKR1B1 (0.45) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL14809032 | 0.82 | GPR84 (0.52) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL14809975 | 0.82 | GPR84 (0.52) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL14810074 | 0.82 | GPR84 (0.52) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL8056020 | 0.82 | GPR84 (0.52) | ALDH1A1MEN1KMT2ACYP1A2THRB | |
| SCHEMBL910472 | 0.82 | GPR84 (0.52) | ALDH1A1MEN1KMT2ACYP1A2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552079-B2 | Water-blown, flame retardant rigid polyurethane foam | BAYER MATERIALSCIENCE LLC (US) | 2013-10-08 | — | — | US | claimed |
| EP-1883664-B1 | HYDROCARBON OR HYDROFLUOROCARBON BLOWN ASTM E4-84 CLASS I RIGID POLYURETHANE FOAMS | BAYER MATERIALSCIENCE LLC (US) | 2010-11-17 | — | — | EP | claimed |
| JP-2009517533-A | — | — | 2009-04-30 | — | — | JP | claimed |
| JP-2008540767-A | — | — | 2008-11-20 | — | — | JP | claimed |
| EP-1883664-A1 | HYDROCARBON OR HYDROFLUOROCARBON BLOWN ASTM E4-84 CLASS I RIGID POLYURETHANE FOAMS | Bayer MaterialScience LLC (US) | 2008-02-06 | — | — | EP | claimed |
| WO-2007075251-A2 | WATER-BLOWN, FLAME RETARDANT RIGID POLYURETHANE FOAM | BAYER MATERIALSCIENCE LLC (US) | 2007-07-05 | — | — | WO | claimed |
| US-20070129452-A1 | Water-blown, flame retardant rigid polyurethane foam | BAYER MATERIALSCIENCE LLC | 2007-06-07 | — | — | US | claimed |
| WO-2006124364-A1 | HYDROCARBON OR HYDROFLUOROCARBON BLOWN ASTM E4-84 CLASS I RIGID POLYURETHANE FOAMS | BAYER MATERIALSCIENCE LLC (US) | 2006-11-23 | — | — | WO | claimed |
| US-20060258762-A1 | Hydrocarbon or hydrofluorocarbon blown ASTM E-84 class I rigid polyurethane foams | BAYER MATERIALSCIENCE LLC | 2006-11-16 | — | — | US | claimed |
| EP-4745170-A1 | METHOD FOR PREPARING A URETHANE GROUP-CONTAINING POLYMER | BASF SE (DE) | 2026-05-20 | — | — | EP | disclosed |
| EP-4745169-A1 | COMPOSITION USEFUL AS COATING, SEALANT OR ADHESIVE | BASF SE (DE) | 2026-05-20 | — | — | EP | disclosed |
| EP-4731701-A1 | METHOD FOR PREPARING A POLYOXYALKYLENE POLYOL | Covestro Deutschland AG (DE) | 2026-04-29 | — | — | EP | disclosed |
| US-12612500-B2 | Heat labile foam-in-place polyurethane foam | BATTELLE SAVANNAH RIVER ALLIANCE LLC (US) | 2026-04-28 | — | — | US | disclosed |
| EP-3819342-B1 | FLEXIBLE POLYURETHANE FOAM, AUTOMOBILE SEAT PAD, AND PRODUCTION METHOD FOR FLEXIBLE POLYURETHANE FOAM | BRIDGESTONE CORP (JP) | 2026-03-18 | — | — | EP | disclosed |
| US-4281110-A | Process for the production of broken down lignin-cellulose silicate copolymers | BLOUNT DAVID H | 1981-07-28 | — | — | US | disclosed |
| US-4258222-A | HYDROGENATION OF FORMOSE SOLUTIONS | BAYER AKTIENGESELLSCHAFT (DE) | 1981-03-24 | — | — | US | disclosed |
| US-4211848-A | UNSATURATED POLYESTER, WATER CONTAINING OXIDATED SILICON COMPOUND | BLOUNT DAVID H (US) | 1980-07-08 | — | — | US | disclosed |
| US-4115320-A | COMBINATION OF A METAL COMPOUND AND A PRIMARY AMINE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-19 | — | — | US | disclosed |
| US-4098730-A | Non-flammable organo-red mud polymers, some of which are electrically conductive, and process for their manufacture | METALLGESELLSCHAFT AKTIENGESELLSCHAFT (DE) | 1978-07-04 | — | — | US | disclosed |
| US-4061697-A | POLYURETHANES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12612500-B2 | Heat labile foam-in-place polyurethane foam | PUF60, OGG1, EIF3L | ALDH1A1 3404/4885MEN1 3489/4885KMT2A 4114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.