Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554691 | 0.79 | ALDH1A1 (0.34) | LMNAALDH1A1MCL1OPRK1SLC18A3 | |
| SCHEMBL4843284 | 0.78 | CA1 (0.34) | LMNAALDH1A1MCL1OPRK1KMT2A | |
| SCHEMBL27751204 | 0.78 | LMNA (0.31) | LMNAALDH1A1MCL1OPRK1 | |
| SCHEMBL1817592 | 0.73 | RIPK1 (0.33) | LMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL28107926 | 0.71 | SLC18A3 (0.44) | LMNAALDH1A1MCL1SLC18A3MAPT | |
| SCHEMBL6677041 | 0.70 | MEN1 (0.35) | ALDH1A1OPRK1KMT2A | |
| SCHEMBL27657788 | 0.70 | — | — | |
| SCHEMBL6108396 | 0.69 | SMN1; SMN2 (0.36) | ALDH1A1MCL1L3MBTL1 | |
| SCHEMBL6107480 | 0.69 | HSD11B1 (0.38) | ALDH1A1 | |
| SCHEMBL6107095 | 0.69 | HSD11B1 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212332-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009033581-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-19 | — | — | WO | disclosed |