Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.35 |
| ▸ | CDK2 | P24941 | 6/20 | 0.33 |
| ▸ | CDC7 | O00311 | 5/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641680 | 0.79 | BRAF (0.49) | BRAFCSNK1DALDH1A2PRKD3CHEK2 | |
| SCHEMBL3434765 | 0.74 | ALDH1A2 (0.32) | BRAFALDH1A2 | |
| SCHEMBL5223920 | 0.74 | MAPK14 (0.37) | BRAFCDK2CDC7CDK1CCNB1 | |
| SCHEMBL5225154 | 0.74 | SLC2A1 (0.46) | CDK2CDK1CCNB1CCNA2SCN9A | |
| SCHEMBL3421116 | 0.74 | MAPK14 (0.37) | BRAFCDK2CDC7DBF4CCNE1 | |
| SCHEMBL2193407 | 0.72 | BRAF (0.61) | BRAFCDK2TGFBR1CDK1NR1I2 | |
| SCHEMBL9989084 | 0.72 | BRAF (0.55) | BRAFCDK2TGFBR1CDK1NR1I2 | |
| SCHEMBL1640122 | 0.71 | TGFBR1 (0.41) | BRAFTGFBR1NR1I2RORC | |
| SCHEMBL5228233 | 0.70 | FFAR1 (0.40) | CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL3434367 | 0.70 | JAK2 (0.35) | CDK2CDC7DBF4CCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231625-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |