⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34349 | 0.73 | POLB (0.48) | — | |
| SCHEMBL1259144 | 0.72 | POLB (0.52) | — | |
| SCHEMBL7959 | 0.69 | SLC9A1 (0.48) | — | |
| SCHEMBL10552820 | 0.66 | TSHR (0.33) | — | |
| SCHEMBL5438355 | 0.66 | ALDH1A1 (0.44) | — | |
| SCHEMBL2871727 | 0.65 | MGAM (0.43) | — | |
| SCHEMBL2866375 | 0.64 | TDO2 (0.39) | — | |
| SCHEMBL15155876 | 0.63 | SLC9A1 (0.56) | — | |
| SCHEMBL4006348 | 0.62 | TSHR (0.41) | — | |
| SCHEMBL2207685 | 0.62 | RAB9A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190216940-A1 | Prodrugs Comprising a Pyroglutamate Linker | ASCENDIS PHARMA A/S (DK) | 2019-07-18 | — | — | US | claimed |
| EP-3303365-A2 | PRODRUGS COMPRISING A PYROGLUTAMATE LINKER | Ascendis Pharma Inc. (US) | 2018-04-11 | — | — | EP | claimed |
| US-20170224829-A1 | Prodrugs Comprising an Aminoalkyl Glycine Linker | ASCENDIS PHARMA A/S (DK) | 2017-08-10 | — | — | US | claimed |
| EP-3193941-A1 | PRODRUGS COMPRISING AN AMINOALKYL GLYCINE LINKER | Ascendis Pharma A/S (DK) | 2017-07-26 | — | — | EP | claimed |
| WO-2016196124-A2 | PRODRUGS COMPRISING A PYROGLUTAMATE LINKER | ASCENDIS PHARMA INC. (US) | 2016-12-08 | — | — | WO | claimed |
| WO-2016020373-A1 | PRODRUGS COMPRISING AN AMINOALKYL GLYCINE LINKER | ASCENDIS PHARMA A/S (DK) | 2016-02-11 | — | — | WO | claimed |
| US-20150057221-A1 | PRODRUG COMPRISING A DRUG LINKER CONJUGATE | ASCENDIS PHARMA AS (DK) | 2015-02-26 | — | — | US | claimed |
| US-8906847-B2 | Prodrug comprising a drug linker conjugate | ASCENDIS PHARMA A/S (DK) | 2014-12-09 | — | — | US | claimed |
| US-8795631-B2 | Radiofluorination | HAMMERSMITH IMANET LIMITED (GB) | 2014-08-05 | — | — | US | claimed |
| US-8377917-B2 | Polymeric prodrug with a self-immolative linker | COMPLEX BIOSYSTEMS GMBH (DE) | 2013-02-19 | — | — | US | claimed |
| WO-2009095479-A2 | PRODRUG COMPRISING A SELF-CLEAVABLE LINKER | ASCENDIS PHARMA AS (DK) | 2009-08-06 | — | — | WO | claimed |
| JP-2008543916-A | — | — | 2008-12-04 | — | — | JP | claimed |
| US-20080241102-A1 | Polymeric Prodrug with a Self-Immolative Linker | COMPLEX BIOSYSTEMS GMBH (DE) | 2008-10-02 | — | — | US | claimed |
| EP-1909845-A2 | N,N-BIS-(2-HYDROXYETHYL) GLYCINE AMIDE AS LINKER IN POLYMER CONJUGATED PRODRUGS | Complex Biosystems GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| JP-2007530485-A | — | — | 2007-11-01 | — | — | JP | claimed |
| WO-2006136586-A2 | N, N-BIS- (2-HYDROXYETHYL) GLYCINE AMIDE AS LINKER IN POLYMER CONJUGATED PRODRUGS | COMPLEX BIOSYSTEMS GMBH (DE) | 2006-12-28 | — | — | WO | claimed |
| EP-1732607-A2 | POLYMERIC PRODRUG WITH A SELF-IMMOLATIVE LINKER | Complex Biosystems GmbH (DE) | 2006-12-20 | — | — | EP | claimed |
| EP-1625855-A1 | Polymeric prodrug with a self-immolative linker | Complex Biosystems GmbH (DE) | 2006-02-15 | — | — | EP | claimed |
| WO-2005099768-A2 | POLYMERIC PRODRUG WITH A SELF-IMMOLATIVE LINKER | COMPLEX BIOSYSTEMS GMBH (DE) | 2005-10-27 | — | — | WO | claimed |
| EP-1579873-A1 | Polymeric prodrugs | Complex Biosystems GmbH (DE) | 2005-09-28 | — | — | EP | claimed |