Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424582 | 0.94 | CRHBP (0.41) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL1631802 | 0.93 | KCNA5 (0.43) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL1629153 | 0.93 | HCRTR2 (0.44) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL1629343 | 0.90 | LMNA (0.44) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL3427591 | 0.90 | UTS2R (0.41) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL1630025 | 0.89 | LMNA (0.46) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL1629105 | 0.88 | HSD11B1 (0.45) | CRHBPCRHR2LMNAHCRTR2KCNA5 | |
| SCHEMBL3424551 | 0.88 | LMNA (0.49) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL1630051 | 0.87 | HCRTR2 (0.44) | CRHBPCRHR2LMNATSHRHCRTR2 | |
| SCHEMBL1630647 | 0.87 | CNR1 (0.43) | CRHBPCRHR2LMNAHCRTR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009092642-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-30 | — | — | WO | disclosed |