Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424582 | 0.96 | CRHBP (0.41) | UTS2RPOLBHTTNPSR1RIPK1 | |
| SCHEMBL1629343 | 0.94 | LMNA (0.44) | UTS2RPOLBHTTNPSR1RIPK1 | |
| SCHEMBL1630544 | 0.91 | HSD11B1 (0.47) | UTS2RPOLBHTTNPSR1RIPK1 | |
| SCHEMBL3422260 | 0.90 | CRHBP (0.41) | UTS2RPOLBHTTNPSR1RIPK1 | |
| SCHEMBL1630647 | 0.89 | CNR1 (0.43) | UTS2RPOLBLMNACRHBPCRHR2 | |
| SCHEMBL1629153 | 0.89 | HCRTR2 (0.44) | POLBHTTNPSR1RIPK1LMNA | |
| SCHEMBL1629076 | 0.87 | LMNA (0.50) | UTS2RPOLBHTTNPSR1LMNA | |
| SCHEMBL1921417 | 0.86 | DPP4 (0.37) | UTS2RPOLBHTTNPSR1RIPK1 | |
| SCHEMBL1629105 | 0.85 | HSD11B1 (0.45) | UTS2RRIPK1LMNACRHBPCRHR2 | |
| SCHEMBL3422507 | 0.85 | CRHBP (0.51) | UTS2RPOLBHTTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009092642-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-30 | — | — | WO | disclosed |