Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427457 | 0.86 | ALDH1A1 (0.50) | MAPTTDP1ALDH1A1ADRA1AKDM4E | |
| SCHEMBL9576976 | 0.83 | HMGCR (0.47) | MAPTTDP1RXRARXRBRXRG | |
| SCHEMBL8295144 | 0.83 | ADRA1A (0.45) | TDP1ALDH1A1ADRA1AKDM4EHPGD | |
| SCHEMBL87519 | 0.82 | CYP1A2 (0.57) | MAPTTDP1RXRARXRBRXRG | |
| SCHEMBL12918718 | 0.82 | HTT (0.52) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL12565602 | 0.82 | ALDH1A1 (0.50) | MAPTTDP1ALDH1A1ADRA1AKDM4E | |
| SCHEMBL250454 | 0.80 | CYP1A2 (0.55) | MAPTTDP1RXRARXRBRXRG | |
| SCHEMBL3091854 | 0.80 | CYP1A2 (0.55) | MAPTTDP1RXRARXRBRXRG | |
| SCHEMBL2034342 | 0.80 | CYP1A2 (0.55) | MAPTTDP1RXRARXRBRXRG | |
| SCHEMBL195800 | 0.80 | CYP1A2 (0.55) | MAPTTDP1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662750-B2 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-02-16 | — | — | US | disclosed |
| US-7662750-B2 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-02-16 | — | — | US | disclosed |
| US-7662750-B2 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-02-16 | — | — | US | disclosed |
| US-20050153366-A1 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-07-14 | — | — | US | disclosed |
| WO-2005057171-A2 | PROTEIN-PROTEIN INTERACTION ANTAGONIST SCREENING LIBRARIES BASED UPON 1,4-DISUBSTITUTED NAPHTHALENES AND RELATED SCAFFOLDS | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153366-A1 | Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds | RIPK4, RIPK2, ATRIP | MAPT 3459/4885TDP1 3151/4885RXRA 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.