Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.75 |
| ▸ | TAS2R38 | P59533 | 3/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | TYR | P14679 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | KIF11 | P52732 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylthiourea SCHEMBL42753 | 0.86 | ALDH1A1 (1.00) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| Phenylthiourea SCHEMBL11820844 | 0.86 | ALDH1A1 (1.00) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| Phenylthiourea SCHEMBL27472859 | 0.84 | ALDH1A1 (0.95) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| Phenylthiourea SCHEMBL29672776 | 0.84 | ALDH1A1 (0.95) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| Phenylthiourea SCHEMBL22494152 | 0.84 | ALDH1A1 (0.95) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| Phenylthiourea SCHEMBL28966870 | 0.84 | ALDH1A1 (0.95) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| Phenylthiourea SCHEMBL6644561 | 0.84 | ALDH1A1 (0.95) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| Phenylthiourea SCHEMBL28211446 | 0.84 | ALDH1A1 (0.95) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| SCHEMBL4991363 | 0.83 | ALDH1A1 (0.53) | ALDH1A1TAS2R38HSD17B10TP53TYR | |
| SCHEMBL725810 | 0.83 | ALDH1A1 (0.75) | ALDH1A1TAS2R38HSD17B10TP53TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1849301-A | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS INC (US) | 2006-10-18 | — | — | CN | claimed |
| EP-1648862-A2 | SUBSTITUTED ARYLTHIOUREA DERIVATIVES USEFUL AS INHIBITORS OF VIRAL REPLICATION | Achillion Pharmaceuticals, Inc. (US) | 2006-04-26 | — | — | EP | claimed |
| US-20050032849-A1 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | claimed |
| WO-2005007601-A2 | SUBSTITUTED ARYLTHIOUREA DERIVATIVES USEFUL AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |
| CN-118619952-A | Aloperine derivative, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-09-10 | — | — | CN | disclosed |
| CN-117164480-A | Method for preparing cyanamide and mercaptan | 华南理工大学 | 2023-12-05 | — | — | CN | disclosed |
| CN-110590785-B | Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71 | 武汉大学 | 2021-02-02 | — | — | CN | disclosed |
| CN-110590785-A | Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71 | 武汉大学 | 2019-12-20 | — | — | CN | disclosed |
| US-7741491-B2 | Diphenylamine-substituted salicylthiazole derivatives and related compounds as phosphotyrosine phosphatase 1B (PTB1B) inhibitors for using as blood-sugar decreasing active ingredients for treating diabetes | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-06-22 | — | — | US | disclosed |
| US-7741491-B2 | Diphenylamine-substituted salicylthiazole derivatives and related compounds as phosphotyrosine phosphatase 1B (PTB1B) inhibitors for using as blood-sugar decreasing active ingredients for treating diabetes | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-06-22 | — | — | US | disclosed |
| US-7718671-B2 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718671-B2 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718671-B2 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1771426-B1 | DIPHENYLAMINE-SUBSTITUTED SALICYLTHIAZOLE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOTYROSINE PHOSPHATASE 1B (PTP1B) INHIBITORS FOR USING AS BLOOD-SUGAR DECREASING ACTIVE INGREDIENTS FOR TREATING DIABETES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-19 | — | — | EP | disclosed |
| US-20070191441-A1 | DIPHENYLAMINE-SUBSTITUTED SALICYLTHIAZOLE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOTYROSINE PHOSPHATASE 1B (PTB1B) INHIBITORS FOR USING AS BLOOD-SUGAR DECREASING ACTIVE INGREDIENTS FOR TREATING DIABETES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191441-A1 | DIPHENYLAMINE-SUBSTITUTED SALICYLTHIAZOLE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOTYROSINE PHOSPHATASE 1B (PTB1B) INHIBITORS FOR USING AS BLOOD-SUGAR DECREASING ACTIVE INGREDIENTS FOR TREATING DIABETES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
| US-20050032849-A1 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191441-A1 | DIPHENYLAMINE-SUBSTITUTED SALICYLTHIAZOLE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOTYROSINE PHOSPHATASE 1B (PTB1B) INHIBITORS FOR USING AS BLOOD-SUGAR DECREASING ACTIVE INGREDIENTS FOR TREATING DIABETES | PPM1B, PPP1R1B, PPM1D | ALDH1A1 1573/4885TAS2R38 3345/4885HSD17B10 3060/4885 |
| US-20050032849-A1 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | TPMT, NAT1, GOT1 | ALDH1A1 261/4885TAS2R38 1111/4885HSD17B10 1273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.