Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836561 | 0.96 | TDP1 (0.36) | TDP1 | |
| SCHEMBL16307424 | 0.69 | — | — | |
| SCHEMBL6854760 | 0.60 | — | — | |
| Bromide SCHEMBL29057789 | 0.58 | TDP1 (0.89) | TDP1 | |
| Bromide SCHEMBL7517638 | 0.58 | — | — | |
| Bromide SCHEMBL6924630 | 0.55 | TDP1 (0.80) | TDP1 | |
| SCHEMBL80808 | 0.52 | — | — | |
| Isobutane SCHEMBL28999947 | 0.52 | — | — | |
| Isobutane SCHEMBL3368265 | 0.52 | — | — | |
| Isobutane SCHEMBL28999929 | 0.52 | ALDH1A1 (0.43) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651682-B1 | PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS BV (NL) | 2010-05-05 | — | — | EP | disclosed |
| EP-1656395-B1 | PROCESS FOR THE PREPARATION OF A METALLOORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS BV (NL) | 2010-04-28 | — | — | EP | disclosed |
| US-7674867-B2 | Process for the preparation of an metal-organic compound comprising at least one imine ligand | DSM IP ASSETS B.V. (NL) | 2010-03-09 | — | — | US | disclosed |
| US-7655592-B2 | Process for the preparation of a metal-organic compound comprising at least one imine ligand | DSM IP ASSETS B.V. (NL) | 2010-02-02 | — | — | US | disclosed |
| US-20080045719-A1 | Process for the Preparation of a Metal-Organic Compound Comprising at Least One Imine Ligand | ARLANXEO NETHERLANDS B.V. (NL) | 2008-02-21 | — | — | US | disclosed |
| US-20080027195-A1 | Process for the Preparation of an Metal-Organic Compound Comprising at Least One Imine Ligand | ARLANXEO NETHERLANDS B.V. (NL) | 2008-01-31 | — | — | US | disclosed |
| EP-1656395-A1 | PROCESS FOR THE PREPARATION OF A METALLOORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP Assets B.V. (NL) | 2006-05-17 | — | — | EP | disclosed |
| EP-1651682-A1 | PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP Assets B.V. (NL) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014664-A1 | PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014663-A1 | PROCESS FOR THE PREPARATION OF AN METALLOORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045719-A1 | Process for the Preparation of a Metal-Organic Compound Comprising at Least One Imine Ligand | ME1, OPRM1, H1-0 | TDP1 4077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.