Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 3/20 | 0.39 |
| ▸ | CHUK | O15111 | 3/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425920 | 0.81 | LCK (0.52) | LCKBTKPI4K2APDPK1RIPK2 | |
| SCHEMBL28136345 | 0.76 | LCK (0.56) | LCKBTKPI4K2APDPK1RIPK2 | |
| SCHEMBL27682000 | 0.76 | LCK (0.56) | LCKBTKPI4K2APDPK1RIPK2 | |
| SCHEMBL30369932 | 0.76 | LCK (0.56) | LCKBTKPI4K2APDPK1RIPK2 | |
| SCHEMBL11890138 | 0.76 | TRPA1 (0.58) | BTKRIPK2JAK2JAK3 | |
| SCHEMBL17500264 | 0.75 | DHODH (0.48) | LCKBTKJAK2JAK3BRD4 | |
| SCHEMBL3663816 | 0.73 | CCNT1 (0.58) | LCKBTKPI4K2ARIPK2IKBKB | |
| SCHEMBL28555354 | 0.71 | KDM4E (0.49) | LCKBTKPI4K2ABRD4MPO | |
| SCHEMBL4285442 | 0.69 | NPC1 (0.45) | PARP1IKBKBKDM4E | |
| SCHEMBL23647144 | 0.69 | PKN1 (0.47) | PARP1IKBKBCHUKPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025872-A2 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2010-03-11 | — | — | WO | disclosed |