Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 14/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187598 | 0.87 | P2RX7 (0.34) | — | |
| SCHEMBL930031 | 0.82 | GRM5 (0.47) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL929359 | 0.82 | ALDH1A1 (0.53) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL929409 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL928677 | 0.81 | GRM5 (0.48) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL3425461 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL929099 | 0.80 | ALDH1A1 (0.60) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL928854 | 0.80 | GRM5 (0.56) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL3428330 | 0.80 | ESR2 (0.44) | ALDH1A1TDP1GAAMAPTGRM5 | |
| SCHEMBL929403 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TDP1GAAMAPTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247590-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | Merz Pharma GmbH & Co. KGaA (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009095254-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |