Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 11/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1059670 | 0.75 | JAK2 (0.41) | USP2DPP4LMNAMEN1KMT2A | |
| SCHEMBL3428156 | 0.68 | ZAP70 (0.45) | USP2MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL3428992 | 0.64 | AURKA (0.49) | TP53MAPTMAPK1HRH4 | |
| SCHEMBL1048871 | 0.61 | ZAP70 (0.66) | JAK3BTKLCK | |
| SCHEMBL12928849 | 0.61 | ZAP70 (0.66) | JAK3BTKLCK | |
| SCHEMBL1058372 | 0.59 | SYK (0.46) | DPP4MAPK1JAK3BTKEGFR | |
| SCHEMBL19654330 | 0.58 | BRD4 (0.60) | USP2LMNAMEN1KMT2AMAPT | |
| SCHEMBL19654326 | 0.58 | BRD4 (0.60) | USP2LMNAMEN1KMT2AMAPT | |
| SCHEMBL17547519 | 0.58 | ULK1 (0.53) | ULK1 | |
| SCHEMBL378949 | 0.57 | SMN1; SMN2 (0.62) | LMNAMEN1KMT2AMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | claimed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | claimed |