Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176541 | 0.84 | S1PR1 (0.48) | S1PR1MAPK1RXRARXRBRXRG | |
| SCHEMBL12805307 | 0.81 | MRGPRX4 (0.53) | S1PR1RXRARXRBRXRGTHRA | |
| SCHEMBL628125 | 0.80 | MAPK1 (0.54) | MAPK1KMT2AL3MBTL1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7840484 | 0.79 | MAPK1 (0.53) | MAPK1KMT2AL3MBTL1KDM4EMEN1 | |
| SCHEMBL3433626 | 0.78 | SCN9A (0.44) | S1PR1MAPK1RXRARXRBRXRG | |
| SCHEMBL856030 | 0.77 | RXRA (0.70) | RXRARXRBRXRGMAOBMRGPRX4 | |
| SCHEMBL3428539 | 0.77 | KMT2A (0.41) | S1PR1MAPK1RXRARXRBRXRG | |
| SCHEMBL17664021 | 0.77 | RXRA (0.53) | S1PR1MAPK1RXRARXRBRXRG | |
| SCHEMBL27480887 | 0.75 | RXRA (0.54) | RXRARXRBRXRGMAOBKMT2A | |
| SCHEMBL16380706 | 0.75 | HTR1B (0.49) | S1PR1THRATHRBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642379-B2 | Aminoacetonitrile derivatives and their use for controlling parasites on warm-blooded animals | NOVARTIS AG (CH) | 2010-01-05 | — | — | US | disclosed |
| US-20080194693-A1 | Aminoacetonitrile Derivatives and Their Use for Controlling Parasites on Warm-Blooded Animals | NOVARTIS AG (CH) | 2008-08-14 | — | — | US | disclosed |
| EP-1758849-A1 | AMINOACETONITRILE DERIVATIVES AND THEIR USE FOR CONTROLLING PARASITES ON WARM-BLOODED ANIMALS | Novartis AG (CH) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121075-A1 | AMINOACETONITRILE DERIVATIVES AND THEIR USE FOR CONTROLLING PARASITES ON WARM-BLOODED ANIMALS | NOVARTIS AG (CH) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194693-A1 | Aminoacetonitrile Derivatives and Their Use for Controlling Parasites on Warm-Blooded Animals | MB, ACHE, ADORA2B | S1PR1 4559/4885MAPK1 3061/4885RXRA 3011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.