SCHEMBL3429430

SCHEMBL3429430

Cc1cc(C(=O)OCOC(=O)c2ccc(N)c(C)c2)ccc1N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.49
CYP3A4 P08684 2/20 0.49
LMNA P02545 1/20 0.49
MAOA P21397 1/20 0.49
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
PTGER4 P35408 3/20 0.43
MAPT P10636 3/20 0.43
TDP1 Q9NUW8 3/20 0.43
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GLA P06280 1/20 0.42
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL868290 0.89 LMNA (0.62) CYP1A2CYP3A4LMNAMAOACA12
SCHEMBL26261263 0.83 CYP1A2 (0.44) CYP1A2CYP3A4LMNAMAOACA12
SCHEMBL14648744 0.83 CA12 (0.50) LMNACA12CA1CA2CA7
SCHEMBL14646616 0.82 CYP1A2 (0.65) CYP1A2CYP3A4LMNAMAPTALDH1A1
SCHEMBL17368429 0.82 ALDH1A1 (0.51) CYP1A2CYP3A4LMNAMAOACA12
SCHEMBL9561324 0.82 CA1 (0.64) CYP1A2CYP3A4LMNAMAOACA12
SCHEMBL753159 0.81 KDM4E (0.62) LMNACA12CA1CA2CA7
SCHEMBL27501815 0.81 MAPT (0.46) CYP1A2CYP3A4LMNAMAOACA12
SCHEMBL7557781 0.81 TDP1 (0.58) LMNAMAPTTDP1ALDH1A1KDM4E
SCHEMBL5674062 0.80 MAPT (0.47) CYP1A2CYP3A4LMNAMAOAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1756186-B1 CATALYTIC PROCESSES PERSTORP SPECIALTY CHEM AB (SE) 2014-01-22 EP disclosed
US-7799874-B2 Catalytic compositions PERSTORP SPECIALTY CHEMICALS AB (SE) 2010-09-21 US disclosed
US-20090182096-A1 CATALYTIC COMPOSITIONS PERSTORP SPECIALTY CHEMICALS AB (SE) 2009-07-16 US disclosed
WO-2008137546-A1 AMINE CATALYST BLEND USEFUL IN THE PRODUCTION OF POLYURETHANE ARTICLES HUNTSMAN PETROCHEMICAL CORPORATION (US) 2008-11-13 WO disclosed
WO-2008137556-A1 AMINE CATALYST BLEND USEFUL IN THE PRODUCTION OF POLYURETHANE ARTICLES HUNTSMAN PETROCHEMICAL CORPORATION (US) 2008-11-13 WO disclosed
US-20080071037-A1 Catalytic Compositions SOLVAY (SOCIETE ANONYME) (BE) 2008-03-20 US disclosed
EP-1756186-A1 CATALYTIC COMPOSITIONS SOLVAY (Société Anonyme) (BE) 2007-02-28 EP disclosed
WO-2005118667-A1 CATALYTIC COMPOSITIONS Solvay (Société Anonyme) (BE) 2005-12-15 WO disclosed
EP-1602676-A1 Catalytic compositions SOLVAY (Société Anonyme) (BE) 2005-12-07 EP disclosed
US-6590057-B1 Reacting isocyanates-2+ and polyethers in the presence of polymerization catalysts, to form moldings having flexibility and puncture resistance; footwear BAYER AKTIENGESELLSCHAFT (DE) 2003-07-08 US disclosed