Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 5/20 | 0.51 |
| ▸ | CCR9 | P51686 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12032535 | 0.91 | ERBB2 (0.66) | ERBB2HSP90AA1HSP90AB1CCR2LMNA | |
| SCHEMBL345093 | 0.86 | CCR9 (0.68) | CCR2CCR9 | |
| SCHEMBL28340 | 0.80 | CCR9 (0.56) | ERBB2HSP90AA1HSP90AB1CCR2CCR9 | |
| SCHEMBL10248530 | 0.78 | CCR9 (0.77) | CCR2CCR9LMNAHTTALDH1A1 | |
| SCHEMBL6534765 | 0.78 | HTR6 (0.65) | ERBB2HSP90AA1HSP90AB1KIF18AALDH1A1 | |
| SCHEMBL3786165 | 0.76 | ERBB2 (0.73) | ERBB2HSP90AA1HSP90AB1CCR2LMNA | |
| SCHEMBL28226727 | 0.75 | KIF18A (0.50) | ERBB2HSP90AA1HSP90AB1CCR2KIF18A | |
| SCHEMBL11027219 | 0.74 | ERBB2 (0.71) | ERBB2HSP90AA1HSP90AB1CCR2LMNA | |
| SCHEMBL16479407 | 0.72 | POLB (0.53) | CCR9LMNAHTTALDH1A1 | |
| SCHEMBL1138730 | 0.72 | ERBB2 (0.68) | ERBB2HSP90AA1HSP90AB1CCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364240-B2 | Aryl sulfonamides | ChemoCentryx. Inc. (US) | 2019-07-30 | — | — | US | disclosed |
| US-9890148-B2 | Aryl sulfonamides | CHEMOCENTRYX, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170369483-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2017-12-28 | — | — | US | disclosed |
| US-20150080351-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC. | 2015-03-19 | — | — | US | disclosed |
| US-20130267492-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2013-10-10 | — | — | US | disclosed |
| US-20120014997-A1 | ARYL SULFONAMIDES | UNGASHE SOLOMON (US) | 2012-01-19 | — | — | US | disclosed |
| US-20090163498-A1 | Aryl Sulfonamides | CHEMOCENTRYX, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-7420055-B2 | Antagonists of the chemokine receptor 9 (CCR9); inhibit TECK ligand; antiinflammatory agents and immunoregulators; inflammatory bowel disease; (2-phenylsulfonamidophenyl)-pyridinyl-methanones; N-[4-chloro-2(pyridine4-carbonyl)-phenyl]4-morpholin-4-yl-benzenesulfonamide | CHEMOCENTRYX, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20060111351-A1 | Aryl sulfonamides | CHEMOCENTRYX, INC. | 2006-05-25 | — | — | US | disclosed |
| WO-2005112925-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050137193-A1 | Aryl sulfonamides | CHEMOCENTREYX | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137193-A1 | Aryl sulfonamides | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
| US-10364240-B2 | Aryl sulfonamides | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
| US-20120014997-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
| US-20060111351-A1 | Aryl sulfonamides | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
| US-20170369483-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
| US-20150080351-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
| US-20090163498-A1 | Aryl Sulfonamides | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
| US-20130267492-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | ERBB2 1543/4885HSP90AA1 2306/4885HSP90AB1 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.