SCHEMBL6534765

SCHEMBL6534765

CNc1ccc(Cl)cc1S(=O)(=O)c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 8/20 0.65
CNR2 P34972 4/20 0.51
KIF18A Q8NI77 1/20 0.50
ERBB2 P04626 1/20 0.48
HSP90AA1 P07900 1/20 0.48
HSP90AB1 P08238 1/20 0.48
HTR1A P08908 1/20 0.43
HTR2A P28223 1/20 0.43
HTR7 P34969 1/20 0.43
CNR1 P21554 2/20 0.42
CYP3A4 P08684 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
MCOLN3 Q8TDD5 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
GLA P06280 1/20 0.41
GAA P10253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28226727 0.84 KIF18A (0.50) HTR6CNR2KIF18AERBB2HSP90AA1
SCHEMBL12032535 0.83 ERBB2 (0.66) KIF18AERBB2HSP90AA1HSP90AB1GAA
SCHEMBL6535210 0.82 LMNA (0.52) HTR6CNR2MAPTCYP2C9GAA
SCHEMBL6534728 0.80 HTR6 (0.44) HTR6CNR2CNR1CYP2C9KDM4E
SCHEMBL14372093 0.79 HTR6 (1.00) HTR6MAPTKDM4EALDH1A1GAA
SCHEMBL342954 0.78 ERBB2 (0.56) KIF18AERBB2HSP90AA1HSP90AB1ALDH1A1
SCHEMBL228959 0.78 KIF18A (0.57) HTR6CNR2KIF18ACYP3A4MAPT
SCHEMBL227808 0.78 KIF18A (0.57) HTR6CNR2KIF18AERBB2HSP90AA1
SCHEMBL3920031 0.78 CCR2 (0.50) KDM4EALDH1A1GLAGAA
SCHEMBL6130586 0.76 PTGES2 (0.54) KDM4EALDH1A1GLAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1011652-A4 NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS UNIV THE SCIENCES IN PHILADELP (US) 2004-12-22 EP disclosed
US-6303630-B1 TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BYADMINISTERING TO A HUMAN DIARYLSULFONE COMPOUND UNIVERSITY OF THE SCIENCES IN PHILADELPHIA 2001-10-16 US disclosed
EP-1011652-A1 NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS University of the Sciences in Philadelphia (US) 2000-06-28 EP disclosed
US-6063790-A TREATMENT OF AIDS UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) 2000-05-16 US disclosed
WO-1999006037-A1 NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) 1999-02-11 WO disclosed