Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28789862 | 0.86 | KDM4E (0.36) | DRD2ADRA2AADRA1AHTR1A | |
| SCHEMBL27822668 | 0.83 | PLAU (0.31) | DRD2DRD3 | |
| SCHEMBL2247023 | 0.82 | DRD2 (0.38) | DRD2TLR8DRD3HTR1A | |
| SCHEMBL3410984 | 0.79 | CYP19A1 (0.37) | DRD2TLR8PDPK1ADRA2AADRA1A | |
| SCHEMBL3430394 | 0.78 | ADRA1A (0.42) | ADRA2AADRA1A | |
| SCHEMBL4109733 | 0.78 | ADRA1A (0.42) | ADRA2AADRA1A | |
| SCHEMBL2240638 | 0.76 | GID4 (0.37) | DRD2TLR8 | |
| SCHEMBL3433618 | 0.75 | IDO1 (0.39) | — | |
| SCHEMBL3412191 | 0.74 | HTR1A (0.42) | DRD2HTR1A | |
| SCHEMBL3432049 | 0.73 | IDO1 (0.39) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262789-A1 | 2-AMINOQUINOLINES | F. Hoffmann-La Roche AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109477-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-11 | — | — | WO | disclosed |