Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
| ▸ | RXRB | P28702 | 2/20 | 0.49 |
| ▸ | RXRG | P48443 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | FABP3 | P05413 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | MARS1 | P56192 | 1/20 | 0.42 |
| ▸ | RPA1 | P27694 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430698 | 0.92 | PPP1CA (0.52) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3430105 | 0.89 | KMT2A (0.54) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3428213 | 0.88 | MEN1 (0.51) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3432282 | 0.85 | RXRA (0.52) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3425186 | 0.85 | CHRNA7 (0.45) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3428855 | 0.85 | PPP1CA (0.50) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3426741 | 0.84 | SLC5A1 (0.52) | KMT2AMEN1PPP1CAPTGS2ALDH1A1 | |
| SCHEMBL1110857 | 0.84 | PPP1CA (0.57) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3434272 | 0.84 | PPP1CA (0.41) | KMT2AMEN1ATMPPP1CARXRA | |
| SCHEMBL3427676 | 0.84 | PPP1CA (0.52) | KMT2AMEN1ATMPPP1CARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |