Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28536867 | 0.89 | MEN1 (0.47) | MEN1KMT2AHSD11B1AKR1C1GRIN2D | |
| SCHEMBL3393922 | 0.89 | MEN1 (0.47) | MEN1KMT2AHSD11B1AKR1C1GRIN2D | |
| SCHEMBL3391147 | 0.83 | HSD11B1 (0.44) | MEN1KMT2AHSD11B1AKR1C1OPRM1 | |
| SCHEMBL11661570 | 0.82 | MEN1 (0.47) | MEN1KMT2AHSD11B1AKR1C1GRIN2D | |
| SCHEMBL1097860 | 0.79 | MEN1 (0.45) | MEN1KMT2AHSD11B1AKR1C1GRIN2D | |
| SCHEMBL3787663 | 0.78 | SMN1; SMN2 (0.45) | MEN1KMT2AMAPK1GAAOPRD1 | |
| SCHEMBL22325834 | 0.76 | HSD11B1 (0.42) | MEN1KMT2AHSD11B1AKR1C1GRIN2D | |
| SCHEMBL5822059 | 0.76 | MEN1 (0.42) | MEN1KMT2AHSD11B1AKR1C1GRIN2D | |
| SCHEMBL4592731 | 0.75 | SIGMAR1 (0.38) | MEN1KMT2AHSD11B1SLC6A2SLC6A4 | |
| SCHEMBL21683027 | 0.75 | HSD11B1 (0.41) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859542-B2 | Triazine compounds as PI3 kinase and mTOR inhibitors | WYETH LLC (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2252296-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009091788-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-23 | — | — | WO | disclosed |