Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257677 | 0.86 | TDP1 (0.46) | TDP1FFAR4CA12CA1CA2 | |
| SCHEMBL344393 | 0.86 | ALDH1A1 (0.42) | EGFRMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL256739 | 0.86 | TDP1 (0.62) | TDP1FFAR4CA12CA1CA2 | |
| SCHEMBL4145981 | 0.84 | TDP1 (0.49) | TDP1ABL1CHEK1AURKADAPK3 | |
| SCHEMBL10047544 | 0.83 | TDP1 (0.49) | TDP1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL3743259 | 0.83 | TDP1 (0.49) | TDP1FFAR4CA12CA1CA2 | |
| SCHEMBL4304248 | 0.83 | MAPT (0.51) | TDP1ALKMAPTKDM4EALDH1A1 | |
| SCHEMBL9125892 | 0.83 | HTT (0.53) | TDP1ABL1CHEK1AURKADAPK3 | |
| SCHEMBL15849811 | 0.82 | CA12 (0.43) | TDP1ABL1CA12CA1CA2 | |
| SCHEMBL1402749 | 0.82 | KDM4E (0.49) | CHEK1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025053850-A1 | COVALENT KRAS-BINDING COMPOUNDS FOR MEDICAL TREATMENT | HYKU BIOSCIENCES INC. (US) | 2025-03-13 | — | — | WO | disclosed |
| US-9643969-B2 | (aza)indolizine derivative and pharmaceutical use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-05-09 | — | — | US | disclosed |
| CN-104592224-B | (azepine) Indoli zine derivatives and medicinal usage thereof | 橘生药品工业株式会社 | 2016-08-03 | — | — | CN | disclosed |
| US-9115144-B2 | Fused heterocyclic derivative and pharmaceutical use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2015-08-25 | — | — | US | disclosed |
| CN-103221412-B | (aza) indolizine derivatives and their pharmaceutical use | Kissei Pharmaceutical Co.,Ltd. (JP) | 2015-08-19 | — | — | CN | disclosed |
| EP-2623505-B1 | (AZA)INDOLIZINE DERIVATIVES AS XANTHINE OXIDASE INHIBITORS | KISSEI PHARMACEUTICAL (JP) | 2015-07-29 | — | — | EP | disclosed |
| CN-104592224-A | (AZA)INDOLIZINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | KISSEI PHARMACEUTICAL | 2015-05-06 | — | — | CN | disclosed |
| US-9023882-B2 | 5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2015-05-05 | — | — | US | disclosed |
| US-20140296537-A1 | FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL USE THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-10-02 | — | — | US | disclosed |
| EP-2749562-A1 | FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2014-07-02 | — | — | EP | disclosed |
| US-20130217878-A1 | (AZA)INDOLIZINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2013-08-22 | — | — | US | disclosed |
| EP-2623505-A1 | (AZA)INDOLIZINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2013-08-07 | — | — | EP | disclosed |
| EP-2415771-B1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | KISSEI PHARMACEUTICAL (JP) | 2013-07-31 | — | — | EP | disclosed |
| CN-103221412-A | (aza) indolizine derivatives and their pharmaceutical use | KISSEI PHARMACEUTICAL | 2013-07-24 | — | — | CN | disclosed |
| US-20120289506-A1 | 5-MEMBERED NITROGEN CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-11-15 | — | — | US | disclosed |
| US-8227500-B2 | 5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-07-24 | — | — | US | disclosed |
| EP-2415771-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-20120015972-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
| US-20100227864-A1 | 5-MEMBERED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-09-09 | — | — | US | disclosed |
| EP-2133331-A1 | 5-MEMBERED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Kissei Pharmaceutical Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296537-A1 | FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL USE THEREOF | XDH, URB2, PON1 | TDP1 890/4885ABL1 3742/4885CHEK1 4761/4885 |
| US-20100227864-A1 | 5-MEMBERED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | XDH, DAO, CBR1 | TDP1 935/4885ABL1 2147/4885CHEK1 4459/4885 |
| US-20130217878-A1 | (AZA)INDOLIZINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | XDH, CHRM1, PON1 | TDP1 232/4885ABL1 1179/4885CHEK1 4223/4885 |
| US-20120015972-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | XDH, INMT, PON1 | TDP1 631/4885ABL1 1835/4885CHEK1 4519/4885 |
| US-20120289506-A1 | 5-MEMBERED NITROGEN CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | XDH, DAO, DDO | TDP1 488/4885ABL1 1606/4885CHEK1 4375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.