Sugi Predict

Sugi Predict / Compounds / SCHEMBL256739

SCHEMBL256739

SCHEMBL256739

CCOc1cc(I)ccc1C(=O)OC

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.62
▸ KDM4E B2RXH2 4/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ ALDH1A1 P00352 3/20 0.46
▸ HTT P42858 2/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ TSHR P16473 3/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ MAPT P10636 4/20 0.42
▸ LMNA P02545 2/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ HPGD P15428 2/20 0.42
▸ ATM Q13315 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ FFAR4 Q5NUL3 1/20 0.41
▸ CA12 O43570 1/20 0.41
▸ CA1 P00915 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ CA7 P43166 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10047544 0.88 TDP1 (0.49) TDP1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL3743259 0.88 TDP1 (0.49) TDP1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL4000105 0.87 CA12 (0.49) TDP1KDM4EALDH1A1SMN1; SMN2TSHR
SCHEMBL343448 0.86 TDP1 (0.47) TDP1KDM4EALDH1A1HTTTSHR
SCHEMBL2226597 0.86 TDP1 (0.48) TDP1KDM4EALDH1A1CYP3A4MAPT
SCHEMBL257677 0.84 TDP1 (0.46) TDP1KDM4EKMT2AALDH1A1HTT
SCHEMBL25788934 0.84 MAOA (0.49) TDP1KDM4EKMT2AALDH1A1TSHR
SCHEMBL3738882 0.84 MAOA (0.49) TDP1KDM4EKMT2AALDH1A1TSHR
SCHEMBL256740 0.83 TSHR (0.51) TDP1KDM4EKMT2AALDH1A1SMN1; SMN2
SCHEMBL1402749 0.83 KDM4E (0.49) KDM4EKMT2AALDH1A1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
CN-116472292-A Modified proteins and protein degrading agents 上海睿跃生物科技有限公司 2023-07-21 — — CN disclosed
US-20230113609-A1 SSTR5 ANTAGONISTS KALLYOPE, INC. 2023-04-13 — — US disclosed
EP-4157888-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS Cullgen (Shanghai), Inc. (CN) 2023-04-05 — — EP disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 — — US disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 — — US disclosed
US-20230050965-A1 SSTR5 ANTAGONISTS KALLYOPE, INC. 2023-02-16 — — US disclosed
US-20230050965-A1 SSTR5 ANTAGONISTS KALLYOPE, INC. 2023-02-16 — — US disclosed
US-20150099777-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-04-09 — — US disclosed
US-20150099777-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-04-09 — — US disclosed
US-8895552-B2 Cyclic amide derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2014-11-25 — — US disclosed
WO-2014142363-A1 SPIRO AZETIDINE ISOXAZOLE DERIVATIVES AND THEIR USE AS SSTR5 ANTAGONISTS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-09-18 — — WO disclosed
US-20130217692-A1 CYCLIC AMIDE DERIVATIVE DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2013-08-22 — — US disclosed
EP-2612848-A1 CYCLIC AMIDE DERIVATIVE Dainippon Sumitomo Pharma Co., Ltd. (JP) 2013-07-10 — — EP disclosed
WO-2012029942-A1 CYCLIC AMIDE DERIVATIVE 大日本住友製薬株式会社 (JP) 2012-03-08 — — WO disclosed
EP-2417121-A1 4, 5-DIHYDRO-1H-PYRAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USES Pfizer Inc. (US) 2012-02-15 — — EP disclosed
US-20120022058-A1 4,5-DIHYDRO-1H-PYRAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USES PFIZER INC. 2012-01-26 — — US disclosed
WO-2010116282-A1 4, 5-DIHYDRO-LH-PYRAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USES PFIZER INC. (US) 2010-10-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230113609-A1 SSTR5 ANTAGONISTS SSTR5, GLP1R, GPR119 TDP1 4211/4885KDM4E 1415/4885KMT2A 2300/4885
US-20150099777-A1 HETEROCYCLIC COMPOUND SSTR5, SSTR4, SSTR2 TDP1 4624/4885KDM4E 3637/4885KMT2A 3500/4885
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 TDP1 136/4885KDM4E 786/4885KMT2A 1342/4885
US-20230050965-A1 SSTR5 ANTAGONISTS SSTR5, GLP1R, GPR119 TDP1 4211/4885KDM4E 1415/4885KMT2A 2300/4885
US-20130217692-A1 CYCLIC AMIDE DERIVATIVE HDAC10, H1-10, H1-0 TDP1 4667/4885KDM4E 2413/4885KMT2A 1199/4885
US-20120022058-A1 4,5-DIHYDRO-1H-PYRAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USES NR3C2, REN, AGTR1 TDP1 4559/4885KDM4E 3652/4885KMT2A 4613/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 TDP1 136/4885KDM4E 786/4885KMT2A 1342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.