SCHEMBL343487

SCHEMBL343487

Cn1[c]n[nH]c(=O)c1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11171039 0.69
SCHEMBL11176350 0.67
SCHEMBL11181614 0.67 TERT (0.35)
SCHEMBL11171036 0.66
SCHEMBL11186130 0.66
SCHEMBL11185317 0.65 NPSR1 (0.38)
SCHEMBL11173748 0.65 PTGES (0.34)
SCHEMBL11172479 0.65 LMNA (0.31)
SCHEMBL11178696 0.65 GAA (0.32)
SCHEMBL11175530 0.64 PDE4A (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 398 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4716232-A 1-(vinyl phosphonate adduct) pyrazolidinones ELI LILLY AND COMPANY (US) 1987-12-29 US claimed
US-4684641-A BACTERICIDES PFIZER INC. (US) 1987-08-04 US claimed
EP-0049855-B1 CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES FOR THEIR PREPARATION F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1986-01-29 EP claimed
EP-0054677-B1 CEPHALOSPORINS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Dr. Karl Thomae GmbH (DE) 1985-05-29 EP claimed
US-4514564-A 7β-(2'-(1\",3\",5\"-Triazepin-4\"-one)-2'-(oxime ether)-acetamido)-3-substituted cephalosporins ELI LILLY AND COMPANY (US) 1985-04-30 US claimed
EP-0049814-B1 CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Dr. Karl Thomae GmbH (DE) 1985-01-09 EP claimed
US-4458072-A CEPHALOSPORIN AND OXACEPHALOSPORIN BACTERICIDES HOFFMANN-LA ROCHE INC. (US) 1984-07-03 US claimed
US-4452784-A ANTIBIOTICS ELI LILLY AND COMPANY (US) 1984-06-05 US claimed
US-4401667-A ANTIBIOTICS WITH PYRIMIDINE SUBSTITUENT KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1983-08-30 US claimed
EP-0008372-B1 EASILY HYDROLYSABLE ESTERS AND ETHERS OF CEPHALOSPORINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1983-01-26 EP claimed
US-4364944-A BACTERICIDAL ANTIBIOTICS DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1982-12-21 US claimed
US-4362725-A ANTIBIOTICS DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1982-12-07 US claimed
EP-0053276-A2 Cephalosporins, process for their preparation and pharmaceutical compositions containing them Dr. Karl Thomae GmbH (DE) 1982-06-09 EP claimed
EP-0049814-A2 Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them Dr. Karl Thomae GmbH (DE) 1982-04-21 EP claimed
EP-0049855-A2 Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-04-21 EP claimed
US-4292428-A ANTIBIOTICS; EASILY HYDROLYZED ESTERS AND ETHERS HOFFMANN-LA ROCHE INC. (US) 1981-09-29 US claimed
EP-0000005-B1 NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATIONS AND THEIR PHARMACEUTICAL COMPOSITIONS F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-10-29 EP claimed
US-4178443-A Derivatives of 7 [-substituted oxyimins acetamido] cephalosporins HOFFMANN-LA ROCHE INC. (US) 1979-12-11 US claimed
EP-4397366-A2 GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA Ardelyx, Inc. (US) 2024-07-10 EP disclosed
US-4178443-A Derivatives of 7 [-substituted oxyimins acetamido] cephalosporins HOFFMANN-LA ROCHE INC. (US) 1979-12-11 US disclosed