Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434073 | 0.97 | ESR2 (0.40) | NR1H2GPR119GSK3BESR2MAP3K5 | |
| SCHEMBL3435442 | 0.89 | GSK3B (0.36) | GSK3B | |
| SCHEMBL3663855 | 0.77 | USP30 (0.42) | NR1H2GPR119ESR2MAP3K5USP30 | |
| SCHEMBL3402193 | 0.73 | GSK3B (0.42) | GSK3BMTOR | |
| SCHEMBL3425658 | 0.73 | KCNMA1 (0.40) | GSK3BMTOR | |
| SCHEMBL3402010 | 0.73 | GSK3B (0.39) | GSK3BMTOR | |
| SCHEMBL927355 | 0.73 | GSK3B (0.39) | GSK3BMTOR | |
| SCHEMBL3399684 | 0.73 | CRBN (0.42) | GSK3BMTOR | |
| SCHEMBL3403493 | 0.71 | GSK3B (0.35) | GSK3B | |
| SCHEMBL3400823 | 0.71 | HTR4 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501728-B2 | Substituted heteroarylamide oxazepinopyrimidone derivatives | SANOFI (FR) | 2013-08-06 | — | — | US | claimed |
| EP-2247598-A1 | SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2010-11-10 | — | — | EP | claimed |
| WO-2009095787-A1 | SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-08-06 | — | — | WO | claimed |
| EP-2247598-A1 | SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009095787-A1 | SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-08-06 | — | — | WO | disclosed |