Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435272 | 0.89 | NR1H2 (0.39) | GSK3B | |
| SCHEMBL3434073 | 0.86 | ESR2 (0.40) | GSK3BHDAC8 | |
| SCHEMBL3398498 | 0.78 | GSK3B (0.38) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3403493 | 0.75 | GSK3B (0.35) | GSK3BNAMPTCYP2D6CYP1A2 | |
| SCHEMBL3402173 | 0.75 | GSK3B (0.45) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3402193 | 0.74 | GSK3B (0.42) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3401042 | 0.74 | GSK3B (0.39) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3400870 | 0.74 | GSK3B (0.42) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3425658 | 0.73 | KCNMA1 (0.40) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3399573 | 0.73 | GSK3B (0.44) | GSK3BCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247598-A1 | SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009095787-A1 | SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-08-06 | — | — | WO | disclosed |