Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9793431 | 0.79 | HTR6 (0.62) | HTR6KMT2ATSHRHTTPOLB | |
| SCHEMBL8510774 | 0.79 | TTR (0.38) | KMT2ATSHRALDH1A1 | |
| SCHEMBL5030908 | 0.79 | HSD11B1 (0.40) | KMT2APOLBFEN1ALOX5APKDM4E | |
| SCHEMBL11306716 | 0.78 | MEN1 (0.31) | KMT2AGAA | |
| SCHEMBL8510448 | 0.75 | NPC1 (0.30) | TSHRHTTALDH1A1 | |
| SCHEMBL7179095 | 0.75 | FEN1 (0.41) | TSHRPOLBFEN1ALOX5APALDH1A1 | |
| SCHEMBL9242466 | 0.74 | HTR6 (0.55) | HTR6KMT2ATSHRHTTPOLB | |
| SCHEMBL8844836 | 0.74 | HTR6 (0.55) | HTR6KMT2ATSHRHTTPOLB | |
| SCHEMBL7178906 | 0.72 | NSD2 (0.45) | KMT2AFEN1ALOX5APKDM4E | |
| SCHEMBL2761711 | 0.72 | MEN1 (0.32) | KMT2AHTTPOLBNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937633-B8 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2010-12-22 | — | — | EP | disclosed |
| EP-1937633-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039741-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |