Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.35 |
| ▸ | FEN1 | P39748 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510774 | 0.81 | TTR (0.38) | ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7179095 | 0.81 | FEN1 (0.41) | ALDH1A1ALOX5APFEN1POLBLMNA | |
| SCHEMBL3435329 | 0.79 | HTR6 (0.46) | ALDH1A1KDM4EKMT2AALOX5APFEN1 | |
| SCHEMBL7178906 | 0.78 | NSD2 (0.45) | RAB9AKDM4EKMT2AALOX5APFEN1 | |
| SCHEMBL8510448 | 0.77 | NPC1 (0.30) | RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7186900 | 0.77 | ALOX5AP (0.45) | ALDH1A1KDM4EALOX5APFEN1SMN1; SMN2 | |
| SCHEMBL2761711 | 0.75 | MEN1 (0.32) | RAB9AALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL9211305 | 0.74 | BAZ2B (0.38) | HSD11B1BAZ2BBAZ2ARAB9AALDH1A1 | |
| SCHEMBL1970261 | 0.74 | HSD11B1 (0.40) | HSD11B1BAZ2BBAZ2ARAB9AALDH1A1 | |
| SCHEMBL7186577 | 0.74 | L3MBTL1 (0.49) | ALDH1A1KMT2AALOX5APFEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| EP-1636175-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004089884-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |