Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1L | O00429 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.32 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436064 | 0.77 | HRH3 (0.40) | DNM1L | |
| SCHEMBL3435738 | 0.76 | HRH3 (0.41) | MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL3435733 | 0.76 | DNM1L (0.38) | DNM1LMAPTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL15888536 | 0.76 | SMN1; SMN2 (0.50) | MAPTTP53ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3435414 | 0.74 | SMN1; SMN2 (0.34) | MAPTSMN1; SMN2TSHRHTTLMNA | |
| SCHEMBL3435748 | 0.74 | L3MBTL1 (0.56) | ALDH1A1SMN1; SMN2RXFP1HPGD | |
| SCHEMBL3550331 | 0.74 | PTGER1 (0.46) | DNM1LALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3435448 | 0.73 | ALDH1A1 (0.38) | MAPTALDH1A1SMN1; SMN2TSHRHTT | |
| SCHEMBL13634279 | 0.73 | DNM1L (0.42) | DNM1LALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL21875377 | 0.72 | SMN1; SMN2 (0.52) | DNM1LMAPTTP53ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | DNM1L 2818/4885MAPT 1330/4885TP53 1649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.