SCHEMBL3435481

SCHEMBL3435481

NC(c1ccccc1)(c1ccccc1)c1ccccc1Cc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 2/20 0.50
HTR2A P28223 1/20 0.46
CALM1 P0DP23 1/20 0.41
BCL2 P10415 1/20 0.39
BCL2L1 Q07817 1/20 0.39
LTA4H P09960 1/20 0.39
HPGD P15428 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
MAPK1 P28482 1/20 0.37
SLC6A2 P23975 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
ALOX5 P09917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8322110 0.78 HTR2A (0.47) HTR2ACALM1BCL2BCL2L1LTA4H
SCHEMBL9563015 0.77 HTR2A (0.41) HTR2ACALM1BCL2BCL2L1LTA4H
SCHEMBL10900432 0.77 HTR2A (0.41) HTR2ACALM1BCL2BCL2L1LMNA
Hydrochloric Acid SCHEMBL28430480 0.77 HTR2A (0.46) HTR2ACALM1BCL2BCL2L1LTA4H
SCHEMBL4199977 0.76 KCNN4 (0.48) KCNN4TAAR1
SCHEMBL10360528 0.76 CYP1A2 (0.42) HTR2ACALM1BCL2BCL2L1HPGD
SCHEMBL3404551 0.76 CYP1A2 (0.42) HTR2ACALM1BCL2BCL2L1HPGD
SCHEMBL5764360 0.75 CALM1 (0.48) HTR2ACALM1BCL2BCL2L1HPGD
SCHEMBL11203718 0.74 HTR2A (0.39) HTR2ACALM1BCL2BCL2L1CYP1A2
SCHEMBL5380250 0.74 KDM4E (0.56) HTR2ACALM1BCL2BCL2L1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2266958-A1 Antiviral agent SHIONOGI & CO., LTD. (JP) 2010-12-29 EP disclosed