Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL218547 | 0.83 | NOS3 (0.52) | NOS3NOS1NOS2CHEK1CHRNB4 | |
| SCHEMBL4696251 | 0.83 | ADORA3 (0.36) | IRAK4 | |
| SCHEMBL6582573 | 0.82 | NOS3 (0.67) | NOS3NOS1NOS2CHEK1CHRNB4 | |
| SCHEMBL6111964 | 0.81 | ADORA3 (0.36) | NOS3NOS1 | |
| SCHEMBL6583088 | 0.71 | NOS1 (0.40) | NOS3NOS1NOS2 | |
| SCHEMBL6584378 | 0.70 | NOS1 (0.44) | NOS3NOS1NOS2 | |
| SCHEMBL422892 | 0.70 | NOS1 (0.36) | NOS3NOS1NOS2 | |
| SCHEMBL218548 | 0.70 | PDCD1LG2 (0.36) | NOS3NOS1NOS2CHEK1IRAK4 | |
| SCHEMBL422891 | 0.69 | NOS1 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL5574244 | 0.67 | NOS1 (0.33) | NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249806-A2 | RESVERATROL FORMULATIONS | Sirtris Pharmaceuticals, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009089011-A2 | RESVERATROL FORMULATIONS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
| EP-1850840-A2 | NOVEL COMPOSITIONS FOR PREVENTING AND TREATING NEURODEGENERATIVE AND BLOOD COAGULATION DISORDERS | Sirtris Pharmaceuticals, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006076681-A2 | NOVEL COMPOSITIONS FOR PREVENTING AND TREATING NEURODEGENERATIVE AND BLOOD COAGULATION DISORDERS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | WO | disclosed |