Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 8/20 | 0.33 |
| ▸ | NOS3 | P29474 | 4/20 | 0.33 |
| ▸ | CBX7 | O95931 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | CPT1A | P50416 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583088 | 0.88 | NOS1 (0.40) | NOS1NOS3CBX7HRH3CPT2 | |
| SCHEMBL218548 | 0.85 | PDCD1LG2 (0.36) | NOS1NOS3CBX7HRH3CPT2 | |
| SCHEMBL6111964 | 0.82 | ADORA3 (0.36) | NOS1NOS3ADORA3 | |
| SCHEMBL218547 | 0.79 | NOS3 (0.52) | NOS1NOS3 | |
| SCHEMBL6584378 | 0.72 | NOS1 (0.44) | NOS1NOS3 | |
| SCHEMBL6585074 | 0.71 | ACACA (0.50) | NOS1NOS3ACACAPOLBALPL | |
| SCHEMBL422891 | 0.70 | NOS1 (0.41) | NOS1NOS3 | |
| SCHEMBL4696251 | 0.70 | ADORA3 (0.36) | ADORA3 | |
| SCHEMBL6583013 | 0.70 | CBX7 (0.41) | NOS1NOS3CBX7 | |
| SCHEMBL6582579 | 0.69 | PDCD1LG2 (0.41) | NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853610-A1 | N-PHENYL BENZAMIDE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006094236-A1 | N-PHENYL BENZAMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |