Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13999697 | 0.84 | ALDH1A1 (0.48) | ALDH1A1HTTMAPK1OPRK1SMN1; SMN2 | |
| SCHEMBL3434191 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HTTMAPK1OPRK1CYP1A2 | |
| SCHEMBL6512224 | 0.83 | OPRK1 (0.49) | ALDH1A1HTTMAPK1OPRK1SMN1; SMN2 | |
| SCHEMBL3436000 | 0.81 | JAK2 (0.48) | ALDH1A1HTTMAPK1OPRK1GRM5 | |
| SCHEMBL3435990 | 0.79 | OPRK1 (0.74) | ALDH1A1HTTMAPK1OPRK1POLB | |
| SCHEMBL14334109 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HTTMAPK1OPRK1SMN1; SMN2 | |
| SCHEMBL3436166 | 0.78 | MAPT (0.57) | ALDH1A1HTTMAPK1POLBMAPT | |
| SCHEMBL20135640 | 0.78 | SSTR2 (0.47) | OPRK1AKT2SSTR2 | |
| SCHEMBL20524637 | 0.77 | ALDH1A1 (0.49) | ALDH1A1HTTMAPK1OPRK1SMN1; SMN2 | |
| SCHEMBL6949066 | 0.77 | MAPK1 (0.49) | ALDH1A1HTTMAPK1GRM5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | ALDH1A1 975/4885HTT 4067/4885MAPK1 1316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.