Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435641 | 0.83 | ALDH1A1 (0.50) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL3435990 | 0.81 | OPRK1 (0.74) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL3434191 | 0.81 | ALDH1A1 (0.50) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL3436000 | 0.78 | JAK2 (0.48) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL22587713 | 0.73 | OPRK1 (0.50) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL29445426 | 0.73 | OPRK1 (0.50) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL29969961 | 0.73 | MAPT (0.51) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL26131983 | 0.73 | MAPT (0.51) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL29445413 | 0.72 | OPRK1 (0.49) | OPRK1ALDH1A1HTTMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL5220902 | 0.72 | TXNRD1 (0.49) | ALDH1A1HTTMAPK1MAPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095339-A1 | DICYANOPYRROLIDINES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |