Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434224 | 0.90 | RXRA (0.42) | RXRARXRBRXRGRPA1MEN1 | |
| SCHEMBL3434938 | 0.89 | RPA1 (0.45) | RXRARXRBRXRGPTGS2PTGS1 | |
| SCHEMBL3434328 | 0.87 | PGR (0.38) | RXRARXRBRXRGPTGS2PTGS1 | |
| SCHEMBL3434215 | 0.86 | PGR (0.44) | RXRARXRBRXRGPTGS2PTGS1 | |
| SCHEMBL1765438 | 0.85 | RPA1 (0.53) | RPA1KDM1AMEN1KMT2AATM | |
| SCHEMBL3434272 | 0.84 | PPP1CA (0.41) | RXRARXRBRXRGPTGS2PTGS1 | |
| SCHEMBL1764882 | 0.79 | CHRNA7 (0.50) | RPA1KDM1APGR | |
| SCHEMBL3435607 | 0.78 | RXRA (0.38) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL3434352 | 0.77 | RPA1 (0.39) | RXRARXRBRXRGPTGS2PTGS1 | |
| SCHEMBL3433402 | 0.76 | CNR2 (0.38) | RPA1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |