Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.38 |
| ▸ | RXRB | P28702 | 6/20 | 0.38 |
| ▸ | RXRG | P48443 | 6/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434328 | 0.91 | PGR (0.38) | RXRARXRBRXRGARCHRNA7 | |
| SCHEMBL3434918 | 0.89 | ALDH1A1 (0.40) | RXRARXRBRXRGXPO1CHRNA7 | |
| SCHEMBL3434224 | 0.87 | RXRA (0.42) | RXRARXRBRXRGARMEN1 | |
| SCHEMBL3434336 | 0.87 | RXRA (0.40) | RXRARXRBRXRGXPO1KDM4E | |
| SCHEMBL1765056 | 0.85 | CHRNA7 (0.50) | RXRARXRBRXRGXPO1CHRNA7 | |
| SCHEMBL3431428 | 0.85 | RXRA (0.47) | RXRARXRBRXRGXPO1CHRNA7 | |
| SCHEMBL3434352 | 0.85 | RPA1 (0.39) | RXRARXRBRXRGCHRNA7KDM4E | |
| SCHEMBL3433402 | 0.85 | CNR2 (0.38) | KDM4EALDH1A1FAAH | |
| SCHEMBL3427741 | 0.82 | RXFP1 (0.41) | RXRARXRBRXRGCHRNA7MAPK1 | |
| SCHEMBL3433370 | 0.82 | ALDH1A1 (0.41) | RXRARXRBRXRGCHRNA7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |