Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 2/20 | 0.59 |
| ▸ | CCND1 | P24385 | 2/20 | 0.59 |
| ▸ | XDH | P47989 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3437050 | 1.00 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EGAAEGFR | |
| SCHEMBL5708463 | 0.83 | CDK4 (0.59) | ALDH1A1MAPTKDM4ECDK4CCND1 | |
| SCHEMBL5708464 | 0.83 | CDK4 (0.59) | ALDH1A1MAPTKDM4ECDK4CCND1 | |
| SCHEMBL32679861 | 0.83 | CDK4 (0.59) | ALDH1A1MAPTKDM4ECDK4CCND1 | |
| SCHEMBL8746740 | 0.82 | KDM4E (0.50) | ALDH1A1MAPTKDM4EGAAEGFR | |
| SCHEMBL14218253 | 0.80 | XDH (0.58) | ALDH1A1MAPTKDM4EGAAEGFR | |
| SCHEMBL2553746 | 0.80 | ERN1 (0.66) | ALDH1A1MAPTGAACDK4CCND1 | |
| SCHEMBL2561644 | 0.80 | ERN1 (0.66) | MAPTKDM4EGAAPOLBCDK4 | |
| SCHEMBL2561641 | 0.80 | ERN1 (0.66) | MAPTKDM4EGAAPOLBCDK4 | |
| SCHEMBL2553748 | 0.80 | ERN1 (0.66) | ALDH1A1MAPTGAACDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| EP-1797064-A4 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2009-06-24 | — | — | EP | disclosed |
| EP-1797064-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029515-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-03-23 | — | — | WO | disclosed |
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | THE HOSPITAL FOR SICK CHILDREN | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | MKI67, CCNA2, CDK4 | ALDH1A1 428/4885MAPT 4694/4885KDM4E 279/4885 |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | MKI67, CALU, CDK4 | ALDH1A1 1908/4885MAPT 2662/4885KDM4E 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.