Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.55 |
| ▸ | CCND1 | P24385 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH5A1 | P51649 | 3/20 | 0.46 |
| ▸ | ABAT | P80404 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1527062 | 0.81 | KDM4E (0.67) | KDM4EPTGS2RAB9AALDH1A1ALDH5A1 | |
| SCHEMBL3437049 | 0.80 | ALDH1A1 (0.59) | XDHKDM4ECDK4CCND1ALDH1A1 | |
| SCHEMBL3437050 | 0.80 | ALDH1A1 (0.59) | XDHKDM4ECDK4CCND1ALDH1A1 | |
| SCHEMBL28714595 | 0.77 | CDK4 (0.55) | XDHKDM4EPTGS2RAB9ACDK4 | |
| SCHEMBL2561644 | 0.77 | ERN1 (0.66) | XDHKDM4ECDK4CCND1MAPT | |
| SCHEMBL2561641 | 0.77 | ERN1 (0.66) | XDHKDM4ECDK4CCND1MAPT | |
| SCHEMBL2553748 | 0.77 | ERN1 (0.66) | XDHCDK4CCND1ALDH1A1MAPT | |
| SCHEMBL2553746 | 0.77 | ERN1 (0.66) | XDHCDK4CCND1ALDH1A1MAPT | |
| SCHEMBL28714596 | 0.77 | CDK4 (0.55) | XDHKDM4EPTGS2RAB9ACDK4 | |
| Caffeoyl Aldehyde SCHEMBL563358 | 0.74 | XDH (1.00) | XDHKDM4EPTGS2RAB9ACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125486-A1 | sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy | ACTION MEDICINES (ES) | 2008-05-29 | — | — | US | disclosed |
| US-20080113947-A1 | 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, or sultosilic acid for example; combination therapy | ACTION MEDICINES (ES) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125486-A1 | sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy | STS, MPST, TST | XDH 3346/4885KDM4E 1472/4885PTGS2 1568/4885 |
| US-20080113947-A1 | 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, or sultosilic acid for example; combination therapy | ARSA, STS, SULT2A1 | XDH 871/4885KDM4E 3830/4885PTGS2 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.